Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 18/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.73 |
| ▸ | INSR | P06213 | 3/20 | 0.70 |
| ▸ | KDR | P35968 | 3/20 | 0.70 |
| ▸ | EGFR | P00533 | 2/20 | 0.70 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.67 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.67 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.67 |
| ▸ | LATS1 | O95835 | 1/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.67 |
| ▸ | LYN | P07948 | 1/20 | 0.67 |
| ▸ | RET | P07949 | 1/20 | 0.67 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.67 |
| ▸ | MET | P08581 | 1/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.67 |
| ▸ | INSRR | P14616 | 1/20 | 0.67 |
| ▸ | FECH | P22830 | 1/20 | 0.67 |
| ▸ | MARK3 | P27448 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL399511 | 1.00 | IGF1R (0.73) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL399509 | 1.00 | IGF1R (0.73) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL401491 | 0.94 | IGF1R (0.69) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL401490 | 0.94 | IGF1R (0.69) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL13812661 | 0.93 | IGF1R (0.73) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL398893 | 0.93 | IGF1R (0.73) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL398891 | 0.93 | IGF1R (0.73) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL13812512 | 0.90 | IGF1R (0.59) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL14472872 | 0.88 | IGF1R (0.72) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL13812487 | 0.88 | IGF1R (0.68) | IGF1RCYP3A4INSRKDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740591-B1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARM INC (US) | 2009-06-17 | — | — | EP | disclosed |