Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 7/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13815483 | 1.00 | HTR2B (0.48) | HTR2BCHRNA7PKMCACNA1HCACNA1C | |
| SCHEMBL13815510 | 0.90 | POLB (0.46) | HTR2BCACNA1HCACNA1C | |
| SCHEMBL13815512 | 0.90 | POLB (0.46) | HTR2BCACNA1HCACNA1C | |
| SCHEMBL13815489 | 0.83 | CACNA1H (0.38) | HTR2BCHRNA7CACNA1HCACNA1C | |
| SCHEMBL13815487 | 0.83 | CACNA1H (0.38) | HTR2BCHRNA7CACNA1HCACNA1C | |
| SCHEMBL2546943 | 0.80 | CACNA1H (0.61) | HTR2BCACNA1HCACNA1C | |
| SCHEMBL17888861 | 0.76 | HTR2B (0.62) | HTR2BCHRNA7PKMKMT2A | |
| SCHEMBL17888859 | 0.74 | HTR2B (0.60) | HTR2BCHRNA7PKMKMT2A | |
| SCHEMBL7533221 | 0.72 | HTR2B (0.60) | HTR2BCHRNA7PKMKMT2A | |
| SCHEMBL2548751 | 0.71 | CACNA1H (0.59) | CACNA1HCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350021-B1 | BRIDGED TETRAHYDRONAPHTHALENE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2013-03-20 | — | — | EP | claimed |
| US-8314253-B2 | Bridged tetrahydronaphthalene derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-11-20 | — | — | US | claimed |
| EP-2350021-B1 | BRIDGED TETRAHYDRONAPHTHALENE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2013-03-20 | — | — | EP | disclosed |
| US-8314253-B2 | Bridged tetrahydronaphthalene derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-11-20 | — | — | US | disclosed |