Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 15/20 | 0.63 |
| ▸ | CACNA1C | Q13936 | 12/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13815530 | 1.00 | CACNA1H (0.63) | CACNA1HCACNA1CCYP3A4MEN1MAPT | |
| SCHEMBL14775786 | 0.90 | CACNA1H (0.76) | CACNA1HCACNA1CCYP3A4MEN1MAPT | |
| SCHEMBL13815496 | 0.90 | CACNA1H (0.76) | CACNA1HCACNA1CCYP3A4MEN1MAPT | |
| SCHEMBL14775840 | 0.90 | CACNA1H (0.76) | CACNA1HCACNA1CCYP3A4MEN1MAPT | |
| SCHEMBL2548054 | 0.90 | CACNA1H (0.76) | CACNA1HCACNA1CCYP3A4MEN1MAPT | |
| SCHEMBL2550924 | 0.90 | CACNA1H (0.76) | CACNA1HCACNA1CCYP3A4MEN1MAPT | |
| SCHEMBL13815485 | 0.90 | CACNA1H (0.76) | CACNA1HCACNA1CCYP3A4MEN1MAPT | |
| SCHEMBL2546929 | 0.85 | CACNA1H (0.69) | CACNA1HCACNA1CCYP3A4MEN1MAPT | |
| SCHEMBL13815514 | 0.85 | CACNA1H (0.69) | CACNA1HCACNA1CCYP3A4MEN1MAPT | |
| SCHEMBL2546650 | 0.85 | CACNA1H (0.69) | CACNA1HCACNA1CCYP3A4MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350021-B1 | BRIDGED TETRAHYDRONAPHTHALENE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2013-03-20 | — | — | EP | claimed |
| US-8314253-B2 | Bridged tetrahydronaphthalene derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-11-20 | — | — | US | claimed |
| EP-2350021-B1 | BRIDGED TETRAHYDRONAPHTHALENE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2013-03-20 | — | — | EP | disclosed |
| US-8314253-B2 | Bridged tetrahydronaphthalene derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-11-20 | — | — | US | disclosed |