Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.35 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 5/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.34 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 3/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1641931 | 0.73 | IGF1R (0.53) | IGF1RCDC7CDK19INSREGFR | |
| SCHEMBL13816025 | 0.71 | IGF1R (0.41) | IGF1RCDK19INSREGFRERBB2 | |
| SCHEMBL1642090 | 0.71 | SLC2A1 (0.47) | IGF1RCDC7CDK19INSREGFR | |
| SCHEMBL1641973 | 0.69 | IGF1R (0.50) | IGF1RCDC7CDK19INSREGFR | |
| SCHEMBL12766485 | 0.67 | IGF1R (0.56) | IGF1RINSREGFRERBB2SYK | |
| SCHEMBL1642000 | 0.66 | IGF1R (0.43) | IGF1RCDC7INSREGFRERBB2 | |
| SCHEMBL13815935 | 0.66 | CYP3A4 (0.35) | IGF1RSYKIKBKBAURKACHUK | |
| Formic Acid SCHEMBL1641976 | 0.65 | IGF1R (0.54) | IGF1RINSREGFRERBB2SYK | |
| SCHEMBL13816259 | 0.65 | SLC2A1 (0.56) | IGF1RINSREGFRERBB2SYK | |
| Formic Acid SCHEMBL1642003 | 0.63 | SLC2A1 (0.54) | IGF1RINSREGFRERBB2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009076140-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-18 | — | — | WO | disclosed |