Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 7/20 | 0.63 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.63 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.63 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.63 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.63 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.63 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OGA | O60502 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1384919 | 0.90 | GRIN1 (0.65) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL1382907 | 0.90 | GRIN1 (0.54) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL1383811 | 0.88 | GRIN1 (0.60) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL1383733 | 0.81 | GRIN2D (0.64) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL12361996 | 0.79 | SRD5A2 (0.46) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL4577390 | 0.77 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL1381738 | 0.75 | GRIN2D (0.63) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL1382197 | 0.75 | GRIN2D (0.52) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL2360496 | 0.73 | IDO1 (0.37) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL12508969 | 0.73 | GRIN1 (0.57) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4814880-B2 | — | — | 2011-11-16 | — | — | JP | claimed |
| US-20080312222-A1 | 4-Benzyledene-Piperidin Derivatives | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2008-12-18 | — | — | US | claimed |
| JP-2008508247-A | — | — | 2008-03-21 | — | — | JP | claimed |
| EP-1773810-B1 | NEW 4-BENZYLIDENE-PIPERIDIN DERIVATIVES | RICHTER GEDEON VEGYESZET (HU) | 2008-02-27 | — | — | EP | claimed |
| EP-1773810-A1 | NEW 4-BENZYLIDENE-PIPERIDIN DERIVATIVES | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 2007-04-18 | — | — | EP | claimed |
| WO-2006010964-A1 | NEW 4-BENZYLIDENE-PIPERIDIN DERIVATIVES | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2006-02-02 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312222-A1 | 4-Benzyledene-Piperidin Derivatives | GRIN2C, GRIN2A, GRIN1 | GRIN1 3/4885GRIN2B 4/4885GRIN2D 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.