Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 13/20 | 0.51 |
| ▸ | ACACA | Q13085 | 13/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | MST1R | Q04912 | 1/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13817862 | 0.81 | ACACB (0.51) | ACACBACACAJAK2NTRK1MET | |
| SCHEMBL2355632 | 0.80 | ACACB (0.59) | ACACBACACAJAK2NTRK1MET | |
| SCHEMBL13817871 | 0.77 | ACACB (0.47) | ACACBACACAHSD17B10 | |
| SCHEMBL13817824 | 0.77 | HTT (0.35) | HTTHPGDHSD17B10 | |
| SCHEMBL11941316 | 0.71 | ACACB (0.65) | ACACBACACAJAK2NTRK1MET | |
| SCHEMBL13817849 | 0.69 | ACACB (0.47) | ACACBACACANTRK2TDP2HTT | |
| SCHEMBL2353461 | 0.69 | ACACB (0.83) | ACACBACACAJAK2NTRK1MET | |
| SCHEMBL2362875 | 0.69 | ACACB (0.63) | ACACBACACAJAK2NTRK1MET | |
| SCHEMBL2361970 | 0.68 | ACACB (0.59) | ACACBACACAJAK2NTRK1MET | |
| SCHEMBL2363264 | 0.68 | ACACB (0.62) | ACACBACACAJAK2NTRK1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547660-B2 | Phenyl-substituted 4-hydroxy-tetrahydropyridones | BAYER AKTIENGESELLSCHAFT (DE) | 2009-06-16 | — | — | US | disclosed |
| US-7547660-B2 | Phenyl-substituted 4-hydroxy-tetrahydropyridones | BAYER AKTIENGESELLSCHAFT (DE) | 2009-06-16 | — | — | US | disclosed |