Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3121972 | 0.99 | KCNA5 (0.53) | KCNA5KCNH2L3MBTL1PKMHTR7 | |
| SCHEMBL1379408 | 0.91 | KCNA5 (0.56) | KCNA5KCNH2HTR7DPP4TSHR | |
| Hydrochloric Acid SCHEMBL3120738 | 0.91 | KCNA5 (0.55) | KCNA5KCNH2HTR7DPP4TSHR | |
| SCHEMBL1379132 | 0.86 | KCNA5 (0.59) | KCNA5KCNH2DPP4HTTTSHR | |
| Hydrochloric Acid SCHEMBL3123502 | 0.85 | KCNA5 (0.58) | KCNA5KCNH2DPP4HTTTSHR | |
| SCHEMBL3117323 | 0.82 | KCNA5 (0.68) | KCNA5KCNH2DPP4 | |
| SCHEMBL1381462 | 0.82 | KCNA5 (0.64) | KCNA5KCNH2DPP4ALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL3116749 | 0.81 | KCNA5 (0.67) | KCNA5KCNH2DPP4KMT2A | |
| Hydrochloric Acid SCHEMBL2904489 | 0.81 | KCNA5 (0.62) | KCNA5KCNH2DPP4ALDH1A1GAA | |
| SCHEMBL3115349 | 0.80 | KCNA5 (0.76) | KCNA5KCNH2DPP4ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667978-B1 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME (US) | 2013-09-04 | — | — | EP | claimed |
| JP-4719151-B2 | — | — | 2011-07-06 | — | — | JP | claimed |
| US-7709476-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-05-04 | — | — | US | claimed |
| US-20080227778-A1 | Isoquinolinone Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2008-09-18 | — | — | US | claimed |
| EP-1667978-A4 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2007-08-29 | — | — | EP | claimed |
| EP-1667978-A2 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2006-06-14 | — | — | EP | claimed |
| WO-2005046578-A2 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2005-05-26 | — | — | WO | claimed |
| EP-1667978-B1 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME (US) | 2013-09-04 | — | — | EP | disclosed |
| EP-1667978-B1 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME (US) | 2013-09-04 | — | — | EP | disclosed |
| US-7709476-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-05-04 | — | — | US | disclosed |
| US-7709476-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-05-04 | — | — | US | disclosed |
| US-7709476-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-05-04 | — | — | US | disclosed |
| US-20080227778-A1 | Isoquinolinone Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2008-09-18 | — | — | US | disclosed |
| US-20080227778-A1 | Isoquinolinone Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2008-09-18 | — | — | US | disclosed |
| US-20080227778-A1 | Isoquinolinone Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2008-09-18 | — | — | US | disclosed |
| EP-1667978-A4 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2007-08-29 | — | — | EP | disclosed |
| EP-1667978-A2 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005046578-A2 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2005-05-26 | — | — | WO | disclosed |
| WO-2005046578-A2 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2005-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227778-A1 | Isoquinolinone Potassium Channel Inhibitors | KCNJ2, KCNQ1, KCNQ2 | KCNA5 23/4885KCNH2 4/4885L3MBTL1 1064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.