SCHEMBL1381979

SCHEMBL1381979

Cc1c(N2CC(CCN)C(C)(C)C2)c(F)cc2c(=O)n(N)c(=O)n(C3CC3)c12

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 10/20 0.39
SCN5A Q14524 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1385935 0.92 KCNH2 (0.39) KCNH2SCN5A
SCHEMBL6491768 0.91 KCNH2 (0.39) KCNH2SCN5A
SCHEMBL1380188 0.88 KCNH2 (0.39) KCNH2
SCHEMBL1382814 0.87 KCNH2 (0.40) KCNH2SCN5A
SCHEMBL1384263 0.85 KCNH2 (0.39) KCNH2SCN5A
Hydrochloric Acid SCHEMBL4527968 0.84 KCNH2 (0.39) KCNH2SCN5A
SCHEMBL4514969 0.83 KCNH2 (0.44) KCNH2SCN5A
Hydrochloric Acid SCHEMBL6475061 0.83 KCNH2 (0.37) KCNH2SCN5A
SCHEMBL6489718 0.83 KCNH2 (0.39) KCNH2SCN5A
Hydrochloric Acid SCHEMBL4518457 0.83 KCNH2 (0.43) KCNH2SCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4811978-B2 2011-11-09 JP claimed
EP-1255739-A1 3-AMINOQUINAZOLIN-2,4-DIONE ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY (US) 2002-11-13 EP claimed
WO-2001053273-A1 3-AMINOQUINAZOLIN-2,4-DIONE ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY (US) 2001-07-26 WO claimed