Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 12/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL977856 | 0.90 | GRM5 (0.54) | F10HDAC3HDAC1HDAC6GRM5 | |
| SCHEMBL975563 | 0.89 | F10 (0.48) | F10HDAC3HDAC1HDAC6GRM5 | |
| SCHEMBL978228 | 0.89 | F10 (0.47) | F10HDAC3HDAC1HDAC6GRM5 | |
| SCHEMBL979622 | 0.88 | HDAC1 (0.58) | F10HDAC3HDAC1HDAC6GRM5 | |
| SCHEMBL976807 | 0.88 | HDAC1 (0.47) | F10HDAC3HDAC1HDAC6GRM5 | |
| SCHEMBL13822776 | 0.88 | HDAC3 (0.56) | F10HDAC3HDAC1HDAC6GRM5 | |
| SCHEMBL977976 | 0.87 | HDAC3 (0.51) | F10HDAC3HDAC1HDAC6NPC1 | |
| SCHEMBL976084 | 0.86 | F10 (0.44) | F10HDAC3HDAC1HDAC6GRM5 | |
| SCHEMBL976157 | 0.86 | F10 (0.48) | F10HDAC3HDAC1HDAC6NPC1 | |
| SCHEMBL976085 | 0.86 | F10 (0.44) | F10HDAC3HDAC1HDAC6GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197552-B1 | NOVEL TETRAHYDROFUSEDPYRIDINES AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2012-11-21 | — | — | EP | claimed |