Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.72 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.72 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.72 |
| ▸ | CHRM3 | P20309 | 18/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.71 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.71 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4427276 | 0.84 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL460823 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL4431395 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL4431348 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL4428588 | 0.83 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL4420338 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL4423049 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL4431257 | 0.81 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL13823185 | 0.81 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL4422424 | 0.79 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544675-B2 | Chemical compounds with dual activity, processes for their preparation and pharmaceutical compositions | UCB, S.A. (BE) | 2009-06-09 | — | — | US | disclosed |