Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 3/20 | 0.32 |
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13824440 | 0.92 | CCR1 (0.52) | CCR1CHRM2CCR5S1PR5HRH1 | |
| SCHEMBL15478348 | 0.90 | CCR1 (0.50) | CCR1CHRM2CCR5S1PR5HTR2B | |
| SCHEMBL12121845 | 0.90 | CCR1 (0.51) | CCR1CHRM2CCR5S1PR5OPRM1 | |
| SCHEMBL13824434 | 0.89 | CCR1 (0.48) | CCR1CHRM2CCR5S1PR5OPRM1 | |
| SCHEMBL10288239 | 0.89 | CCR1 (0.49) | CCR1CHRM2CCR5S1PR5KCNH2 | |
| SCHEMBL14419958 | 0.89 | CCR1 (0.49) | CCR1CHRM2CCR5S1PR5KCNH2 | |
| SCHEMBL14579627 | 0.88 | CCR1 (0.49) | CCR1CHRM2CCR5S1PR5OPRM1 | |
| SCHEMBL14420122 | 0.88 | CCR1 (0.49) | CCR1CHRM2CCR5S1PR5OPRM1 | |
| SCHEMBL13824432 | 0.87 | CCR1 (0.48) | CCR1CHRM2CCR5S1PR5HRH1 | |
| SCHEMBL10287557 | 0.86 | CCR1 (0.49) | CCR1CHRM2CCR5S1PR5OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541365-B2 | Chemokine receptor antagonists and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-06-02 | — | — | US | disclosed |
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |