Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.73 |
| ▸ | PDE1A | P54750 | 8/20 | 0.73 |
| ▸ | PDE1B | Q01064 | 8/20 | 0.73 |
| ▸ | PDE1C | Q14123 | 8/20 | 0.73 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.73 |
| ▸ | PDE6A | P16499 | 3/20 | 0.72 |
| ▸ | PDE2A | O00408 | 2/20 | 0.72 |
| ▸ | PDE6D | O43924 | 2/20 | 0.72 |
| ▸ | PDE9A | O76083 | 2/20 | 0.72 |
| ▸ | PDE6G | P18545 | 2/20 | 0.72 |
| ▸ | PDE4A | P27815 | 2/20 | 0.72 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.72 |
| ▸ | PDE6B | P35913 | 2/20 | 0.72 |
| ▸ | PDE6C | P51160 | 2/20 | 0.72 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.72 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.72 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12823772 | 0.93 | PDE5A (0.84) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL13694 | 0.91 | PDE5A (0.87) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL8256987 | 0.87 | PDE5A (0.82) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL8256126 | 0.86 | PDE5A (0.73) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL8211499 | 0.85 | PDE5A (0.67) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL12823625 | 0.85 | PDE5A (0.84) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL5537 | 0.84 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL24430082 | 0.84 | PDE5A (0.88) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL974583 | 0.83 | PDE5A (0.89) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL14752434 | 0.83 | PDE5A (0.87) | PDE5APDE1APDE1BPDE1CPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049695-B1 | 2-PHENYL SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS | BAYER AG (DE) | 2002-02-13 | — | — | EP | disclosed |