Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2280463 | 0.87 | BACE1 (0.48) | BACE1HTR2BNPC1RAB9AMEN1 | |
| Formic Acid SCHEMBL2285591 | 0.82 | BACE1 (0.44) | BACE1HTR2BNPC1RAB9AMEN1 | |
| SCHEMBL2285600 | 0.78 | NPC1 (0.39) | BACE1HTR2BNPC1RAB9AMEN1 | |
| SCHEMBL13825332 | 0.77 | BACE1 (0.46) | BACE1KCNH2HTR2BMEN1MAPT | |
| SCHEMBL7870847 | 0.74 | BACE1 (0.61) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL2282997 | 0.72 | BACE1 (0.64) | BACE1HTR2BNPC1RAB9AMEN1 | |
| SCHEMBL2283004 | 0.72 | BACE1 (0.64) | BACE1HTR2BNPC1RAB9AMEN1 | |
| SCHEMBL2282323 | 0.70 | BACE1 (0.56) | BACE1HTR2BCTSDICMTROCK1 | |
| Formic Acid SCHEMBL2281201 | 0.70 | BACE1 (0.55) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL7868119 | 0.69 | BACE1 (0.63) | BACE1KCNH2BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-B1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-11-14 | — | — | EP | disclosed |