Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24364391 | 0.72 | PRCP (0.38) | CHRNB2CHRNA4 | |
| SCHEMBL13825628 | 0.71 | CHRM2 (0.36) | HTR1AADRA1BMEN1KMT2A | |
| SCHEMBL29081786 | 0.69 | PRCP (0.36) | DDB1CRBNMEN1KMT2ACHRNB2 | |
| SCHEMBL31145132 | 0.69 | PRCP (0.36) | DDB1CRBNMEN1KMT2ACHRNB2 | |
| SCHEMBL24365235 | 0.69 | PRCP (0.36) | DDB1CRBNMEN1KMT2ACHRNB2 | |
| SCHEMBL29081784 | 0.69 | PRCP (0.36) | DDB1CRBNMEN1KMT2ACHRNB2 | |
| SCHEMBL24384272 | 0.67 | DDB1 (0.40) | DDB1CRBN | |
| SCHEMBL14396985 | 0.67 | DDB1 (0.40) | DDB1CRBN | |
| SCHEMBL9420060 | 0.65 | PRCP (0.40) | MEN1KMT2ACHRNA7 | |
| SCHEMBL18601881 | 0.65 | DDB1 (0.35) | SMN1; SMN2DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2522664-A1 | Piperidine derivatives as NK1 antagonists | OPKO Health, Inc. (US) | 2012-11-14 | — | — | EP | disclosed |