Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 11/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.73 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | AGER | Q15109 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3615307 | 0.85 | KCNA5 (1.00) | KCNA5KCNH2DPP4MAPK8 | |
| SCHEMBL3617133 | 0.85 | KCNA5 (1.00) | KCNA5KCNH2DPP4MAPK8 | |
| SCHEMBL3624319 | 0.85 | KCNA5 (0.85) | KCNA5KCNH2DPP4MAPK8 | |
| SCHEMBL3621295 | 0.85 | KCNA5 (1.00) | KCNA5KCNH2DPP4MAPK8 | |
| SCHEMBL3620184 | 0.84 | KCNA5 (0.84) | KCNA5KCNH2DPP4MAPK8 | |
| SCHEMBL3624106 | 0.83 | KCNA5 (0.81) | KCNA5KCNH2DPP4MAPK8 | |
| SCHEMBL1386096 | 0.83 | KCNA5 (0.53) | KCNA5KCNH2CYP19A1MAPK8CYP11B1 | |
| SCHEMBL3613934 | 0.82 | KCNA5 (0.81) | KCNA5KCNH2DPP4MAPK8 | |
| SCHEMBL3615364 | 0.81 | KCNA5 (0.79) | KCNA5KCNH2DPP4MAPK8 | |
| SCHEMBL3615733 | 0.81 | KCNA5 (0.79) | KCNA5KCNH2DPP4MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4824563-B2 | — | — | 2011-11-30 | — | — | JP | claimed |
| US-7763614-B2 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-07-27 | — | — | US | claimed |
| US-20070054892-A1 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2007-03-08 | — | — | US | claimed |
| US-7763614-B2 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-07-27 | — | — | US | disclosed |
| US-7763614-B2 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-07-27 | — | — | US | disclosed |
| US-7763614-B2 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-07-27 | — | — | US | disclosed |
| US-20070054892-A1 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054892-A1 | Isoquinoline potassium channel inhibitors | KCNQ1, KCNQ2, KCNQ5 | KCNA5 14/4885KCNH2 5/4885CYP19A1 3880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.