Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.72 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.72 |
| ▸ | PIK3CD | O00329 | 13/20 | 0.71 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.71 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.71 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.71 |
| ▸ | PLK4 | O00444 | 1/20 | 0.71 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.71 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.71 |
| ▸ | GAK | O14976 | 1/20 | 0.71 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.71 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.71 |
| ▸ | STK16 | O75716 | 1/20 | 0.71 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.71 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.71 |
| ▸ | NQO2 | P16083 | 1/20 | 0.71 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.71 |
| ▸ | JAK1 | P23458 | 1/20 | 0.71 |
| ▸ | TYK2 | P29597 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13828692 | 0.91 | PIK3CA (0.62) | PIK3CAPIK3CBPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL13828689 | 0.89 | PIK3CA (0.69) | PIK3CAPIK3CBPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL2184342 | 0.88 | PIK3CA (0.67) | PIK3CAPIK3CBPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL190425 | 0.85 | PIK3CA (0.74) | PIK3CAPIK3CBPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL189894 | 0.85 | PIK3CA (0.73) | PIK3CAPIK3CBPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL13828542 | 0.84 | PIK3CA (0.62) | PIK3CAPIK3CBPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL190021 | 0.84 | PIK3CA (1.00) | PIK3CAPIK3CBPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL190889 | 0.84 | PIK3CA (0.79) | PIK3CAPIK3CBPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL1309749 | 0.83 | PIK3CA (0.75) | PIK3CAPIK3CBPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL1192254 | 0.83 | PIK3CA (0.76) | PIK3CAPIK3CBPIK3CDPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9801888-B2 | Pyrimidine compounds as mTOR and PI3K inhibitors | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2017-10-31 | — | — | US | disclosed |
| US-20160136176-A1 | NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2016-05-19 | — | — | US | disclosed |
| US-9315491-B2 | Pyrimidine compounds as mTOR and PI3K inhibitors | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2016-04-19 | — | — | US | disclosed |
| US-20140178360-A1 | NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS | DCB-USA LLC (US) | 2014-06-26 | — | — | US | disclosed |
| US-20120288492-A1 | NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS | DCB-USA LLC (US) | 2012-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120288492-A1 | NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS | MTOR, PIK3CA, TYMS | PIK3CA 2/4885PIK3CB 7/4885PIK3CD 5/4885 |
| US-20160136176-A1 | NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS | MTOR, PIK3CA, TYMS | PIK3CA 2/4885PIK3CB 7/4885PIK3CD 5/4885 |
| US-20140178360-A1 | NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS | MTOR, PIK3CA, TYMS | PIK3CA 2/4885PIK3CB 7/4885PIK3CD 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.