Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.37 |
| ▸ | RARG | P13631 | 5/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RARA | P10276 | 2/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.34 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16925442 | 1.00 | RARB (0.37) | RARBRARGACACBCYP3A4CYP2C9 | |
| SCHEMBL13740539 | 0.88 | PTPN11 (0.39) | CYP3A4CYP2C9MAPTCYP2D6ALDH1A1 | |
| SCHEMBL13738565 | 0.88 | PTPN11 (0.39) | CYP3A4CYP2C9MAPTCYP2D6ALDH1A1 | |
| SCHEMBL16921533 | 0.83 | RARB (0.41) | RARBRARGACACBCYP3A4ALDH1A1 | |
| SCHEMBL13737615 | 0.82 | RARB (0.39) | RARBRARGACACBCYP3A4ALDH1A1 | |
| SCHEMBL31303687 | 0.82 | RARB (0.39) | RARBRARGACACBCYP3A4ALDH1A1 | |
| SCHEMBL31303689 | 0.82 | RARB (0.39) | RARBRARGACACBCYP3A4ALDH1A1 | |
| SCHEMBL13738717 | 0.82 | RARB (0.39) | RARBRARGACACBCYP3A4ALDH1A1 | |
| SCHEMBL13831258 | 0.82 | RARB (0.39) | RARBRARGACACBCYP3A4ALDH1A1 | |
| SCHEMBL17451854 | 0.82 | RARB (0.39) | RARBRARGACACBCYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012154204-A1 | HYDROXAMIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS | ACHAOGEN, INC. (US) | 2012-11-15 | — | — | WO | disclosed |