Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 15/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 15/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 13/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2873589 | 0.82 | KCNH2 (1.00) | KCNH2HDAC1HDAC2HDAC3LTA4H | |
| SCHEMBL29598145 | 0.82 | KCNH2 (1.00) | KCNH2HDAC1HDAC2HDAC3LTA4H | |
| SCHEMBL1065997 | 0.78 | KCNH2 (0.70) | KCNH2HDAC1HDAC2HDAC3LTA4H | |
| SCHEMBL28941544 | 0.78 | KCNH2 (0.50) | KCNH2HDAC1HDAC2HDAC3LTA4H | |
| SCHEMBL21999632 | 0.78 | KCNH2 (0.70) | KCNH2HDAC1HDAC2HDAC3LTA4H | |
| SCHEMBL1323041 | 0.78 | KCNH2 (0.70) | KCNH2HDAC1HDAC2HDAC3LTA4H | |
| SCHEMBL3467228 | 0.78 | KCNH2 (0.70) | KCNH2HDAC1HDAC2HDAC3LTA4H | |
| SCHEMBL29689598 | 0.78 | KCNH2 (0.50) | KCNH2HDAC1HDAC2HDAC3LTA4H | |
| SCHEMBL8234801 | 0.76 | KCNH2 (0.72) | KCNH2HDAC1HDAC2HDAC3LTA4H | |
| SCHEMBL13494207 | 0.74 | KCNH2 (0.70) | KCNH2HDAC1HDAC2HDAC3LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012149540-A1 | INHIBITORS OF HISTONE DEACETYLASE | THE BROAD INSTITUTE INC (US) | 2012-11-01 | — | — | WO | disclosed |