Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1417201 | 0.93 | MAPK14 (0.58) | MAPK14MAPK11MAPK13MAPK12DHODH | |
| SCHEMBL1383355 | 0.92 | MAPK14 (0.48) | MAPK14MAPK11MAPK13MAPK12CYP3A4 | |
| SCHEMBL1382646 | 0.90 | MAPK14 (0.57) | MAPK14MAPK11MAPK13MAPK12CYP3A4 | |
| SCHEMBL1382843 | 0.89 | MAPK14 (0.56) | MAPK14MAPK11MAPK13MAPK12CYP3A4 | |
| SCHEMBL5794358 | 0.88 | MAPK14 (0.50) | MAPK14MAPK11MAPK13MAPK12CYP3A4 | |
| SCHEMBL1386438 | 0.84 | MAPK14 (0.50) | MAPK14MAPK11CYP3A4CYP2C9KIT | |
| SCHEMBL1383736 | 0.82 | MAPK14 (0.66) | MAPK14MAPK11 | |
| SCHEMBL1416913 | 0.81 | MAPK14 (0.62) | MAPK14MAPK11CYP3A4CYP2C9KIT | |
| SCHEMBL1384339 | 0.81 | MAPK14 (0.54) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL1382334 | 0.81 | MAPK14 (0.58) | MAPK14MAPK11MAPK13MAPK12CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4838121-B2 | — | — | 2011-12-14 | — | — | JP | claimed |
| JP-2007521278-A | — | — | 2007-08-02 | — | — | JP | claimed |
| EP-1641764-A1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | Novartis AG (CH) | 2006-04-05 | — | — | EP | claimed |
| WO-2005009973-A1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2005-02-03 | — | — | WO | claimed |