Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 8/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | UHRF1 | Q96T88 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13833660 | 0.75 | MAPT (0.66) | POLBMAPTTDP1L3MBTL1APEX1 | |
| SCHEMBL13833837 | 0.71 | POLB (0.64) | POLBMAPTTDP1L3MBTL1APEX1 | |
| SCHEMBL13833836 | 0.70 | POLB (0.53) | POLBMAPTTDP1L3MBTL1APEX1 | |
| SCHEMBL13833676 | 0.70 | APEX1 (0.72) | POLBMAPTAPEX1KDM4ERAB9A | |
| SCHEMBL13833651 | 0.70 | POLB (0.53) | POLBMAPTTDP1L3MBTL1APEX1 | |
| SCHEMBL13833599 | 0.70 | APEX1 (0.64) | POLBMAPTTDP1L3MBTL1APEX1 | |
| SCHEMBL13833777 | 0.70 | MAPT (0.58) | POLBMAPTTDP1L3MBTL1APEX1 | |
| SCHEMBL13833778 | 0.70 | POLB (0.58) | POLBMAPTTDP1L3MBTL1APEX1 | |
| SCHEMBL13735857 | 0.70 | POLB (0.58) | POLBMAPTTDP1L3MBTL1APEX1 | |
| SCHEMBL13833663 | 0.70 | APEX1 (0.74) | POLBMAPTTDP1L3MBTL1APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012154888-A1 | COMPOUNDS FOR TREATING PROTEIN FOLDING DISORDERS | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2012-11-15 | — | — | WO | disclosed |