Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.70 |
| ▸ | FLT3 | P36888 | 18/20 | 0.70 |
| ▸ | KIT | P10721 | 9/20 | 0.70 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.70 |
| ▸ | CSF1R | P07333 | 6/20 | 0.61 |
| ▸ | FLT1 | P17948 | 6/20 | 0.61 |
| ▸ | LCK | P06239 | 5/20 | 0.61 |
| ▸ | FLT4 | P35916 | 5/20 | 0.61 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.61 |
| ▸ | RET | P07949 | 4/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.61 |
| ▸ | HIPK4 | Q8NE63 | 4/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.61 |
| ▸ | AURKA | O14965 | 3/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.61 |
| ▸ | FRK | P42685 | 3/20 | 0.61 |
| ▸ | CLK2 | P49760 | 3/20 | 0.61 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1382188 | 0.92 | KDR (0.70) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL4737316 | 0.91 | KDR (0.68) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL1383101 | 0.89 | KDR (0.67) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL1383493 | 0.87 | KDR (0.72) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL5253141 | 0.87 | KDR (0.70) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL4736063 | 0.87 | KDR (0.70) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL4740182 | 0.86 | KDR (0.72) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL4738714 | 0.86 | KDR (0.63) | KDRFLT3KITPDGFRBAURKB | |
| SCHEMBL1380731 | 0.86 | KDR (0.72) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL4740220 | 0.86 | KDR (0.72) | KDRFLT3KITPDGFRBCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4810427-B2 | — | — | 2011-11-09 | — | — | JP | claimed |
| WO-2008080110-A1 | METHODS FOR TREATING MACULAR EDEMA AND PATHOLOGIC OCULAR ANGIOGENESIS USING A NEUROPROTECTIVE AGENT AND A RECEPTOR TYROSINE KINASE INHIBITOR | ALCON, INC. (CH) | 2008-07-03 | — | — | WO | claimed |
| EP-1850839-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON INC. (CH) | 2007-11-07 | — | — | EP | claimed |
| WO-2006091801-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON, INC. (CH) | 2006-08-31 | — | — | WO | claimed |
| EP-1638941-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2006-03-29 | — | — | EP | claimed |
| WO-2004113304-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-29 | — | — | WO | claimed |
| EP-1850839-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON INC. (CH) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006091801-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON, INC. (CH) | 2006-08-31 | — | — | WO | disclosed |