Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | RXRB | P28702 | 5/20 | 0.37 |
| ▸ | RXRA | P19793 | 4/20 | 0.37 |
| ▸ | RXRG | P48443 | 3/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.37 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19197805 | 0.78 | CARM1 (0.45) | CARM1SLC6A4RXRBRXRARXRG | |
| SCHEMBL2262294 | 0.76 | BCL2L1 (0.42) | RXRBRXRARXRGMRGPRX4 | |
| SCHEMBL4185667 | 0.76 | AR (0.61) | ARMRGPRX4 | |
| SCHEMBL18648267 | 0.76 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DSLC6A4 | |
| SCHEMBL31180258 | 0.75 | STS (0.42) | POLBRXRBRXRARXRGMRGPRX4 | |
| SCHEMBL12239013 | 0.75 | ST14 (0.46) | MAOBRXRBRXRARXRGMRGPRX4 | |
| SCHEMBL7700911 | 0.74 | SLC6A4 (0.62) | PDE4APDE4BPDE4CPDE4DSLC6A4 | |
| SCHEMBL31312989 | 0.74 | BCL2L1 (0.54) | RXRBRXRARXRGMRGPRX4 | |
| SCHEMBL31180242 | 0.73 | STS (0.44) | RXRBRXRARXRGMRGPRX4 | |
| SCHEMBL3421695 | 0.73 | SLC6A4 (0.60) | PDE4APDE4BPDE4CPDE4DSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012147518-A1 | NOVEL 3-HYDROXYISOTHIAZOLE 1-OXIDE DERIVATIVE | 持田製薬株式会社 (JP) | 2012-11-01 | — | — | WO | disclosed |