SCHEMBL13837232

SCHEMBL13837232

CCCCc1nc2c(N)nc3ccc(N)cc3c2n1Cc1ccc(CN)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 1.00
TLR8 Q9NR97 5/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13968072 0.93 TLR7 (0.86) TLR7TLR8
SCHEMBL13976710 0.89 TLR7 (0.80) TLR7TLR8
SCHEMBL30577190 0.87 TLR7 (1.00) TLR7TLR8
SCHEMBL13837354 0.87 TLR7 (1.00) TLR7TLR8
SCHEMBL13976720 0.87 TLR7 (0.77) TLR7TLR8
Hydrochloric Acid SCHEMBL15881955 0.86 TLR7 (0.98) TLR7TLR8
SCHEMBL13837318 0.86 TLR7 (1.00) TLR7TLR8
SCHEMBL15703349 0.84 TLR7 (1.00) TLR7TLR8
SCHEMBL13968061 0.83 TLR7 (0.97) TLR7TLR8
SCHEMBL13968074 0.83 TLR7 (1.00) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10208037-B2 Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds THE UNIVERSITY OF KANSAS (US) 2019-02-19 US disclosed
US-10208037-B2 Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds THE UNIVERSITY OF KANSAS (US) 2019-02-19 US disclosed
US-20180134701-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS THE UNIVERSITY OF KANSAS 2018-05-17 US disclosed
US-20180134701-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS THE UNIVERSITY OF KANSAS 2018-05-17 US disclosed
US-20180134701-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS THE UNIVERSITY OF KANSAS 2018-05-17 US disclosed
US-20170260184-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS UNIV KANSAS (US) 2017-09-14 US disclosed
US-20170260184-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS UNIV KANSAS (US) 2017-09-14 US disclosed
US-20170260184-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS UNIV KANSAS (US) 2017-09-14 US disclosed
US-20170029421-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS UNIV KANSAS (US) 2017-02-02 US disclosed
US-20170029421-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS UNIV KANSAS (US) 2017-02-02 US disclosed
US-9441005-B2 Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds UNIVERSITY OF KANSAS (US) 2016-09-13 US disclosed
US-20140256922-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2014-09-11 US disclosed
US-20140256922-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2014-09-11 US disclosed
US-20140256922-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2014-09-11 US disclosed
US-8728486-B2 Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds UNIVERSITY OF KANSAS (US) 2014-05-20 US disclosed
US-8728486-B2 Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds UNIVERSITY OF KANSAS (US) 2014-05-20 US disclosed
US-8728486-B2 Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds UNIVERSITY OF KANSAS (US) 2014-05-20 US disclosed
US-20120294885-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS THE UNIVERSITY OF KANSAS (US) 2012-11-22 US disclosed
US-20120294885-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS THE UNIVERSITY OF KANSAS (US) 2012-11-22 US disclosed
US-20120294885-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS THE UNIVERSITY OF KANSAS (US) 2012-11-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180134701-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS TLR7, TLR8, TLR3 TLR7 1/4885TLR8 2/4885
US-20170029421-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS TLR7, TLR8, TLR3 TLR7 1/4885TLR8 2/4885
US-20120294885-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS TLR7, TLR8, TLR3 TLR7 1/4885TLR8 2/4885
US-10208037-B2 Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds TLR7, TLR8, TLR3 TLR7 1/4885TLR8 2/4885
US-20140256922-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS TLR7, TLR8, TLR3 TLR7 1/4885TLR8 2/4885
US-20170260184-A1 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS TLR7, TLR8, TLR3 TLR7 1/4885TLR8 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.