Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 14/20 | 0.46 |
| ▸ | WNT1 | P04628 | 9/20 | 0.46 |
| ▸ | GSK3B | P49841 | 10/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | CLK3 | P49761 | 2/20 | 0.42 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13838324 | 0.91 | DYRK1A (0.47) | DYRK1AWNT1GSK3BAXLMERTK | |
| SCHEMBL13838354 | 0.89 | DYRK1A (0.46) | DYRK1AWNT1GSK3BAXLMERTK | |
| SCHEMBL13838356 | 0.89 | DYRK1A (0.46) | DYRK1AWNT1GSK3BAXLMERTK | |
| SCHEMBL13728453 | 0.87 | EP300 (0.44) | DYRK1AWNT1GSK3BEP300 | |
| SCHEMBL13838400 | 0.85 | DYRK1A (0.50) | DYRK1AWNT1GSK3BAXLMERTK | |
| SCHEMBL13838355 | 0.82 | DYRK1A (0.46) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL13838430 | 0.81 | DYRK1A (0.45) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL13838556 | 0.80 | IL2 (0.44) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL13838532 | 0.80 | DYRK1A (0.44) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL13727775 | 0.79 | DYRK1A (0.43) | DYRK1AWNT1GSK3BCLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012151355-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2012-11-08 | — | — | WO | disclosed |