Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13840444 | 0.93 | KMT2A (0.43) | KMT2AMEN1SMN1; SMN2HTTGAA | |
| SCHEMBL13840452 | 0.90 | MEN1 (0.47) | KMT2AMEN1SMN1; SMN2HTTGAA | |
| SCHEMBL13840446 | 0.83 | MEN1 (0.44) | KMT2AMEN1SMN1; SMN2HTTGAA | |
| SCHEMBL10114635 | 0.68 | KDM4E (0.69) | KMT2AMEN1SMN1; SMN2HTTGAA | |
| SCHEMBL10113951 | 0.68 | KDM4E (0.69) | KMT2AMEN1SMN1; SMN2HTTGAA | |
| SCHEMBL13840441 | 0.67 | HSD17B10 (0.50) | KMT2AMEN1SMN1; SMN2HTTGAA | |
| SCHEMBL13840445 | 0.67 | GNRHR (0.45) | KMT2AMEN1GAANPSR1JAK1 | |
| SCHEMBL10114287 | 0.67 | SMN1; SMN2 (0.60) | KMT2AMEN1SMN1; SMN2HTTGAA | |
| SCHEMBL13840439 | 0.67 | KDM4E (0.59) | KMT2AMEN1SMN1; SMN2HTTGAA | |
| SCHEMBL14424365 | 0.66 | POLB (0.48) | KMT2ASMN1; SMN2HTTGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534892-B2 | Sulfonamide compound | SHIONOGI & CO., LTD. (JP) | 2009-05-19 | — | — | US | disclosed |
| US-20070287710-A1 | Piperidinediyl-containing sulfonamide; NPY Y5 receptor antagonist activity; antiobesity agent or anorectic agent | SHIONOGI & CO., LTD. (JP) | 2007-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287710-A1 | Piperidinediyl-containing sulfonamide; NPY Y5 receptor antagonist activity; antiobesity agent or anorectic agent | NPY5R, NPY1R, NPY2R | KMT2A 1321/4885MEN1 2970/4885SMN1; SMN2 2915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.