Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 8/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 3/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 2/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.36 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.36 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.36 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.36 |
| ▸ | NEK2 | P51955 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397860 | 0.86 | TNK2 (0.44) | TNK2KDM4EIGF1RPDE1CPDE1A | |
| SCHEMBL397861 | 0.86 | TNK2 (0.44) | TNK2KDM4EIGF1RPDE1CPDE1A | |
| SCHEMBL17893109 | 0.79 | TNK2 (0.39) | TNK2KDM4EIGF1RPDE1CBTK | |
| SCHEMBL17892473 | 0.79 | TNK2 (0.39) | TNK2KDM4EIGF1RPDE1CBTK | |
| SCHEMBL1128672 | 0.78 | TNK2 (0.63) | TNK2IGF1RPIK3CAPIK3CBMTOR | |
| SCHEMBL1129633 | 0.78 | TNK2 (0.63) | TNK2IGF1RPIK3CAPIK3CBMTOR | |
| SCHEMBL1128676 | 0.78 | TNK2 (0.63) | TNK2IGF1RPIK3CAPIK3CBMTOR | |
| SCHEMBL1129637 | 0.78 | TNK2 (0.63) | TNK2IGF1RPIK3CAPIK3CBMTOR | |
| SCHEMBL1129441 | 0.78 | FGFR2 (0.45) | TNK2IGF1RPDE1CPDE1APDE1B | |
| SCHEMBL19917134 | 0.76 | PDE1C (0.47) | TNK2IGF1RPDE1CPDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534797-B2 | 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS, INC. (US) | 2009-05-19 | — | — | US | disclosed |
| US-7534797-B2 | 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS, INC. (US) | 2009-05-19 | — | — | US | disclosed |