Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18082552 | 0.90 | MAPK1 (0.52) | SMN1; SMN2TSHRPOLBHPGDPKM | |
| SCHEMBL15200271 | 0.89 | TSHR (0.60) | SMN1; SMN2TSHRPOLBHPGDPKM | |
| SCHEMBL12385793 | 0.89 | TSHR (0.60) | SMN1; SMN2TSHRPOLBHPGDPKM | |
| SCHEMBL12322244 | 0.89 | TSHR (0.60) | SMN1; SMN2TSHRPOLBHPGDPKM | |
| SCHEMBL11158442 | 0.82 | TSHR (0.65) | SMN1; SMN2TSHRPOLBHPGDPKM | |
| SCHEMBL18485330 | 0.80 | TSHR (0.50) | SMN1; SMN2TSHRPOLBHPGDPKM | |
| SCHEMBL2687912 | 0.79 | HPGD (0.49) | SMN1; SMN2TSHRPOLBHPGDPKM | |
| SCHEMBL2687909 | 0.79 | HPGD (0.49) | SMN1; SMN2TSHRPOLBHPGDPKM | |
| SCHEMBL12437066 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2TSHRPOLBHPGDPKM | |
| SCHEMBL12513454 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2TSHRPOLBHPGDPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528140-B2 | Substituted pyrrolo[3,2-d]pyrimidines as glycogen synthase kinase (GSK) inhibitors | TEIJIN LIMITED (JP) | 2009-05-05 | — | — | US | disclosed |
| US-7528140-B2 | Substituted pyrrolo[3,2-d]pyrimidines as glycogen synthase kinase (GSK) inhibitors | TEIJIN LIMITED (JP) | 2009-05-05 | — | — | US | disclosed |