Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 15/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13096429 | 0.90 | CSF1R (0.51) | CSF1RKITFLT3NTRK1LCK | |
| Trifluoroacetic Acid SCHEMBL16594771 | 0.86 | CSF1R (0.49) | CSF1RKITFLT3 | |
| SCHEMBL13844025 | 0.85 | CSF1R (0.47) | CSF1RKITFLT3NTRK1LCK | |
| SCHEMBL13843961 | 0.85 | CSF1R (0.53) | CSF1RKITFLT3 | |
| SCHEMBL13884213 | 0.81 | CSF1R (0.69) | CSF1RKITFLT3 | |
| SCHEMBL13884302 | 0.80 | CSF1R (0.55) | CSF1RKITFLT3 | |
| SCHEMBL13884105 | 0.80 | CSF1R (0.65) | CSF1RKITFLT3 | |
| SCHEMBL13884594 | 0.80 | CSF1R (0.58) | CSF1RKITFLT3 | |
| Trifluoroacetic Acid SCHEMBL2944022 | 0.78 | CSF1R (0.35) | CSF1RKITFLT3 | |
| SCHEMBL13179765 | 0.78 | CSF1R (0.57) | CSF1RKITFLT3NTRK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009058801-A1 | USE OF CFMS INHIBITOR FOR TREATING OR PREVENTING BONE CANCER AND THE BONE LOSS AND BONE PAIN ASSOCIATED WITH BONE CANCER | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-05-07 | — | — | WO | disclosed |
| WO-2007124369-A2 | METHOD OF INHIBITING C KIT KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-01 | — | — | WO | disclosed |
| WO-2007048088-A2 | METHOD OF INHIBITING FLT3 KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-26 | — | — | WO | disclosed |