Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.56 |
| ▸ | CDK2 | P24941 | 4/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13845497 | 0.89 | CHEK1 (0.76) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14218885 | 0.88 | CHEK1 (0.65) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL13845589 | 0.86 | CHEK1 (0.63) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931086 | 0.86 | CHEK1 (0.80) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14218616 | 0.84 | CHEK1 (0.54) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14218611 | 0.84 | CHEK1 (0.77) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14231851 | 0.84 | CHEK1 (0.72) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14231853 | 0.83 | CHEK1 (0.61) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14232212 | 0.83 | CHEK1 (0.74) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14543054 | 0.82 | CHEK1 (0.56) | CHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009061781-A1 | NOVEL MODULATORS OF CELL CYCLE CHECKPOINTS AND THEIR USE IN COMBINATION WITH CHECKPOINT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2009-05-14 | — | — | WO | disclosed |
| WO-2008045266-A2 | PYRAZOLOPYRIMIDIWES AS CYCLIN DEPENDENT KINASE INHIBITOR | SCHERING CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2007044441-A2 | USE OF PYRAZOLO [1 , 5 -A] PYRIMIDINE DERIVATIVES FOR INHIBITING PROTEIN KINASES METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |