Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.53 |
| ▸ | TTK | P33981 | 10/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13954834 | 0.81 | MAPKAPK5 (0.46) | AURKAAURKBCHEK1 | |
| SCHEMBL8240135 | 0.80 | AURKA (0.58) | AURKAAURKBTTKFLT3 | |
| SCHEMBL8240563 | 0.78 | AURKA (0.53) | AURKAAURKBTTKFLT3 | |
| SCHEMBL8246210 | 0.77 | AURKA (0.55) | AURKAAURKBTTKFLT3 | |
| SCHEMBL8240570 | 0.77 | AURKA (0.63) | AURKAAURKBTTKFLT3CHEK1 | |
| SCHEMBL8241005 | 0.75 | AURKA (0.64) | AURKAAURKBTTKFLT3CHEK1 | |
| SCHEMBL13954585 | 0.74 | AURKA (0.55) | AURKAAURKBTTKFLT3CHEK1 | |
| SCHEMBL8240574 | 0.74 | AURKA (0.59) | AURKAAURKBTTKFLT3 | |
| SCHEMBL8239708 | 0.74 | AURKA (0.62) | AURKAAURKBTTKFLT3 | |
| SCHEMBL8239744 | 0.73 | AURKA (0.64) | AURKAAURKBTTKFLT3CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009061781-A1 | NOVEL MODULATORS OF CELL CYCLE CHECKPOINTS AND THEIR USE IN COMBINATION WITH CHECKPOINT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2009-05-14 | — | — | WO | disclosed |
| WO-2009017701-A2 | ANTI-MITOTIC AGENT AND AURORA KINASE INHIBITOR COMBINATION AS ANTI-CANCER TREATMENT | SCHERING CORPORATION (US) | 2009-02-05 | — | — | WO | disclosed |