Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 4/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 3/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21064056 | 1.00 | CHRM2 (0.40) | CHRM2CHRM1CHRM3CETPNR1H2 | |
| SCHEMBL24212059 | 1.00 | CHRM2 (0.40) | CHRM2CHRM1CHRM3CETPNR1H2 | |
| SCHEMBL4038626 | 0.91 | CETP (0.44) | CHRM2CHRM1CHRM3CETPNR1H2 | |
| SCHEMBL4071602 | 0.91 | CETP (0.44) | CHRM2CHRM1CHRM3CETPNR1H2 | |
| SCHEMBL14319923 | 0.91 | CETP (0.44) | CHRM2CHRM1CHRM3CETPNR1H2 | |
| SCHEMBL759059 | 0.91 | CETP (0.44) | CHRM2CHRM1CHRM3CETPNR1H2 | |
| SCHEMBL759308 | 0.91 | CETP (0.44) | CHRM2CHRM1CHRM3CETPNR1H2 | |
| SCHEMBL31699337 | 0.88 | NR1H2 (0.40) | CHRM2CHRM1CHRM3NR1H2PREP | |
| SCHEMBL24874973 | 0.86 | CHRM2 (0.36) | CHRM2CHRM1CHRM3CETPNR1H2 | |
| SCHEMBL13096648 | 0.85 | CHRM2 (0.47) | CHRM2CHRM1CHRM3NR1H2PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009059943-A1 | 4-BENZYLAMINO-1-CARBOXYACYL-PIPERIDINE DERIVATIVES AS CETP INHIBITORS USEFUL FOR THE TREATMENT OF DISEASES SUCH AS HYPERLIPIDEMIA OR ARTERIOSCLEROSIS | NOVARTIS AG (CH) | 2009-05-14 | — | — | WO | disclosed |