Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 13/20 | 0.44 |
| ▸ | MAP3K7 | O43318 | 12/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13846263 | 0.99 | IRAK4 (0.44) | IRAK4MAP3K7LRRK2NTRK1CCNT1 | |
| SCHEMBL13846297 | 0.94 | LRRK2 (0.43) | IRAK4MAP3K7LRRK2NTRK1CCNT1 | |
| SCHEMBL13846369 | 0.94 | LRRK2 (0.46) | LRRK2NTRK1CCNT1CDK2CDK9 | |
| SCHEMBL13846280 | 0.94 | LRRK2 (0.44) | IRAK4MAP3K7LRRK2NTRK1CCNT1 | |
| SCHEMBL13846298 | 0.92 | LRRK2 (0.46) | IRAK4MAP3K7LRRK2NTRK1CCNT1 | |
| SCHEMBL13846362 | 0.92 | LRRK2 (0.44) | IRAK4MAP3K7LRRK2NTRK1CCNE1 | |
| SCHEMBL3716988 | 0.91 | JAK2 (0.51) | IRAK4MAP3K7LRRK2CCNT1CCNE1 | |
| SCHEMBL3709279 | 0.89 | JAK2 (0.51) | IRAK4MAP3K7LRRK2CCNT1CCNE1 | |
| SCHEMBL13846264 | 0.89 | LRRK2 (0.42) | LRRK2NTRK1CCNT1CCNE1CDK2 | |
| SCHEMBL3714920 | 0.85 | JAK2 (0.48) | MAP3K7LRRK2NTRK1CCNT1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064835-A1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-05-22 | — | — | WO | disclosed |