Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 6/20 | 0.43 |
| ▸ | PIM1 | P11309 | 4/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3984374 | 0.84 | PRKCQ (0.58) | HDAC3HDAC1HDAC2HDAC6PRKCQ | |
| SCHEMBL13846480 | 0.77 | PRKCQ (0.51) | HDAC3HDAC1HDAC2HDAC6PRKCQ | |
| SCHEMBL13620030 | 0.76 | PRKCQ (0.49) | HDAC3HDAC1HDAC2HDAC6PRKCQ | |
| SCHEMBL13846554 | 0.76 | PRKCQ (0.62) | HDAC3HDAC1HDAC2HDAC6PRKCQ | |
| SCHEMBL13846611 | 0.75 | PRKCQ (0.60) | HDAC3HDAC1HDAC2HDAC6PRKCQ | |
| SCHEMBL13846604 | 0.75 | PRKCQ (0.60) | HDAC3HDAC1HDAC2HDAC6PRKCQ | |
| SCHEMBL13846606 | 0.74 | PRKCQ (0.51) | HDAC3HDAC1HDAC2HDAC6PRKCQ | |
| SCHEMBL13846553 | 0.74 | PRKCQ (0.60) | HDAC3HDAC1HDAC2HDAC6PRKCQ | |
| SCHEMBL13846563 | 0.74 | PRKCQ (0.60) | HDAC3HDAC1HDAC2HDAC6PRKCQ | |
| SCHEMBL3986930 | 0.74 | PRKCQ (0.72) | PRKCQPIM1PRKCDPIM3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866286-B1 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-05-27 | — | — | EP | disclosed |