Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | MTOR | P42345 | 4/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.48 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 3/20 | 0.45 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10328308 | 0.87 | MTOR (0.60) | MTORPIK3CAPIK3CBPIK3CDPIK3C2B | |
| SCHEMBL13848004 | 0.83 | PIK3CA (0.70) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL12091756 | 0.81 | PIK3CA (0.55) | MTORPIK3CAPIK3CBPIK3CDPIK3C2B | |
| SCHEMBL10327879 | 0.80 | PIK3CA (0.57) | MTORPIK3CAPIK3CBPIK3CDPIK3C2B | |
| SCHEMBL10327901 | 0.80 | PIK3CA (0.68) | PIK3CA | |
| SCHEMBL10327679 | 0.79 | PIK3CA (0.48) | MTORPIK3CAPIK3CBPIK3CDPIK3C2B | |
| SCHEMBL3994331 | 0.78 | PIK3CA (0.58) | MTORPIK3CAPIK3CBPIK3CDPIK3C2B | |
| SCHEMBL10327749 | 0.78 | PIK3CA (0.65) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL10328006 | 0.77 | PIK3CA (0.68) | MTORPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4113962 | 0.77 | PIK3CA (0.50) | MTORPIK3CAPIK3CBPIK3CDPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |