Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 4/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.55 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 5/20 | 0.47 |
| ▸ | BCR | P11274 | 5/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3442067 | 0.91 | SLC2A1 (0.60) | SLC2A1MAPK8MAPK9MAPK10KDR | |
| SCHEMBL3442630 | 0.88 | MAPK8 (0.68) | SLC2A1MAPK8MAPK9MAPK10KDR | |
| SCHEMBL3442220 | 0.86 | SLC2A1 (0.62) | SLC2A1MAPK8MAPK9MAPK10KDR | |
| SCHEMBL14267260 | 0.85 | MAPK8 (0.67) | SLC2A1MAPK8MAPK9MAPK10KDR | |
| SCHEMBL5227243 | 0.82 | SLC2A1 (0.64) | SLC2A1MAPK8MAPK9MAPK10KDR | |
| SCHEMBL3443704 | 0.82 | SLC2A1 (0.66) | SLC2A1MAPK8MAPK9MAPK10KDR | |
| SCHEMBL3442618 | 0.81 | SLC2A1 (0.62) | SLC2A1MAPK8MAPK9MAPK10KDR | |
| SCHEMBL13105468 | 0.81 | SLC2A1 (0.65) | SLC2A1MAPK8MAPK9MAPK10KDR | |
| SCHEMBL3441707 | 0.81 | SLC2A1 (0.64) | SLC2A1MAPK8MAPK9MAPK10KDR | |
| SCHEMBL3441885 | 0.81 | SLC2A1 (0.65) | SLC2A1MAPK8MAPK9MAPK10KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828185-B1 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2009-05-06 | — | — | EP | disclosed |