Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.74 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.74 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.64 |
| ▸ | MTOR | P42345 | 3/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.54 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.53 |
| ▸ | AKT1 | P31749 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10327966 | 0.93 | PIK3CA (0.84) | PIK3CAMAP3K12PIK3R1PIK3CDPIK3CB | |
| SCHEMBL13016782 | 0.88 | PIK3CA (0.76) | PIK3CAMAP3K12PIK3R1PIK3CDPIK3CB | |
| SCHEMBL13848123 | 0.87 | PIK3CA (0.70) | PIK3CAMAP3K12PIK3R1PIK3CDPIK3CB | |
| SCHEMBL10328219 | 0.86 | PIK3CA (0.66) | PIK3CAMAP3K12PIK3R1PIK3CDPIK3CB | |
| SCHEMBL10327687 | 0.86 | PIK3CA (0.66) | PIK3CAMAP3K12PIK3R1PIK3CDPIK3CB | |
| SCHEMBL10327633 | 0.86 | PIK3CA (0.78) | PIK3CAMAP3K12PIK3R1PIK3CDPIK3CB | |
| SCHEMBL13848122 | 0.85 | PIK3CA (0.72) | PIK3CAMAP3K12PIK3R1PIK3CDPIK3CB | |
| SCHEMBL10327890 | 0.85 | PIK3CA (1.00) | PIK3CAMAP3K12PIK3R1PIK3CDPIK3CB | |
| SCHEMBL10328191 | 0.84 | PIK3CA (0.74) | PIK3CAMAP3K12PIK3R1PIK3CDPIK3CB | |
| SCHEMBL2811686 | 0.84 | PIK3CA (0.74) | PIK3CAMAP3K12PIK3R1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |