Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 5/20 | 0.46 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13848204 | 0.90 | PIK3CA (0.55) | PIK3CAPIK3R1MTORPIK3CBPIK3CG | |
| SCHEMBL3992707 | 0.86 | PIK3CA (0.51) | PIK3CAPIK3CBPIK3CGCYP11B2PRKDC | |
| SCHEMBL10327964 | 0.85 | PIK3CA (0.69) | PIK3CAPIK3R1MTORPIK3CBPIK3CG | |
| SCHEMBL10327850 | 0.82 | PIK3CA (0.70) | PIK3CAPIK3R1MTORPIK3CBPIK3CG | |
| SCHEMBL13848119 | 0.81 | PIK3CA (0.53) | PIK3CAPIK3R1MTORPIK3CBPIK3CG | |
| SCHEMBL10328181 | 0.81 | PIK3CA (0.71) | PIK3CAPIK3R1MTORPIK3CBPIK3CG | |
| SCHEMBL13848198 | 0.80 | PIK3CA (0.60) | PIK3CAPIK3R1MTORPIK3CBPIK3CG | |
| SCHEMBL10328141 | 0.79 | PIK3CA (0.72) | PIK3CAPIK3R1MTORPIK3CBMAP3K12 | |
| SCHEMBL12091905 | 0.79 | PIK3CA (0.54) | PIK3CAPIK3R1MTORPIK3CBPIK3CG | |
| SCHEMBL10327794 | 0.77 | PIK3CA (0.63) | PIK3CAPIK3R1MTORPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |