Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.55 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 7/20 | 0.55 |
| ▸ | DRD4 | P21917 | 7/20 | 0.55 |
| ▸ | DRD3 | P35462 | 7/20 | 0.55 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4110203 | 0.90 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3R1PIK3CBMAP3K12 | |
| SCHEMBL4123927 | 0.86 | PIK3CA (0.58) | PIK3CAPIK3CDPIK3R1PIK3CBMAP3K12 | |
| SCHEMBL3988513 | 0.84 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3R1PIK3CBMAP3K12 | |
| SCHEMBL4123039 | 0.83 | PIK3CA (0.50) | PIK3CAPIK3CDPIK3R1PIK3CBMAP3K12 | |
| SCHEMBL3994777 | 0.82 | PIK3CA (0.72) | PIK3CAPIK3CDPIK3R1PIK3CBMAP3K12 | |
| SCHEMBL3995666 | 0.81 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3R1PIK3CBMAP3K12 | |
| SCHEMBL13848172 | 0.81 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3R1PIK3CBMAP3K12 | |
| SCHEMBL13848122 | 0.79 | PIK3CA (0.72) | PIK3CAPIK3CDPIK3R1PIK3CBMAP3K12 | |
| SCHEMBL10327966 | 0.78 | PIK3CA (0.84) | PIK3CAPIK3CDPIK3R1PIK3CBMAP3K12 | |
| SCHEMBL3993858 | 0.78 | AOC3 (0.52) | PIK3CAPIK3CDPIK3R1PIK3CBMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |