Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034420 | 0.90 | MAPK14 (0.40) | MAPK14MAPK11RIPK2ABL1BCR | |
| SCHEMBL4035041 | 0.90 | BRAF (0.45) | MAPK14 | |
| SCHEMBL4031894 | 0.88 | NR1I2 (0.43) | MAPK14NR1I2 | |
| SCHEMBL4033769 | 0.87 | MAPK14 (0.41) | MAPK14MAPK11RIPK2NR1I2 | |
| SCHEMBL303116 | 0.85 | NR1I2 (0.40) | MAPK14NR1I2 | |
| SCHEMBL4031354 | 0.84 | MAPK14 (0.39) | MAPK14MAPK11RIPK2ABL1BCR | |
| SCHEMBL4034585 | 0.84 | BRAF (0.43) | MAPK14 | |
| SCHEMBL302056 | 0.84 | TP53 (0.46) | MAPK14 | |
| SCHEMBL304557 | 0.84 | MAPK14 (0.39) | MAPK14MAPK11RIPK2NR1I2 | |
| SCHEMBL4033513 | 0.82 | BRAF (0.47) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725544-B1 | 3-[4-HETEROCYCLYL-1,2,3-TRIAZOL-1-YL]-N-ARYL-BENZAMIDES AS INHIBITORS OF THE CYTOKINES PRODUCTION FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM PHARMA (US) | 2009-05-27 | — | — | EP | disclosed |