Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.35 |
| ▸ | FRK | P42685 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13848802 | 0.91 | BRAF (0.37) | BRAFLYNMAPK9MAPK14 | |
| SCHEMBL13887477 | 0.90 | LYN (0.47) | BRAFLYNMAPK9 | |
| SCHEMBL13887435 | 0.90 | MAPK14 (0.39) | BRAFLYNMAPK9MAPK14EPHA3 | |
| SCHEMBL13848893 | 0.87 | MAPK14 (0.38) | BRAFMAPK14EPHA3FRK | |
| SCHEMBL13848734 | 0.84 | MAPK14 (0.39) | BRAFMAPK14EPHA3FRK | |
| SCHEMBL13848947 | 0.81 | LYN (0.56) | BRAFLYNMAPK9 | |
| SCHEMBL13848824 | 0.80 | BRAF (0.47) | BRAF | |
| SCHEMBL13848778 | 0.80 | BRAF (0.38) | BRAF | |
| SCHEMBL13887490 | 0.79 | BRAF (0.49) | BRAFLYNMAPK9 | |
| SCHEMBL13848736 | 0.79 | BRAF (0.48) | BRAFLYNMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725544-B1 | 3-[4-HETEROCYCLYL-1,2,3-TRIAZOL-1-YL]-N-ARYL-BENZAMIDES AS INHIBITORS OF THE CYTOKINES PRODUCTION FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM PHARMA (US) | 2009-05-27 | — | — | EP | disclosed |