Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CFD | P00746 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042250 | 0.89 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL13849020 | 0.83 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL13849014 | 0.76 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7434132 | 0.76 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL5846742 | 0.75 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL13849056 | 0.74 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCFD | |
| SCHEMBL4037982 | 0.71 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4044216 | 0.71 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL4041704 | 0.70 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DCFD | |
| SCHEMBL7435677 | 0.69 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487797-B1 | HETERO-BRIDGE SUBSTITUTED 8-ARYLQUINOLINE PDE4 INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2009-05-27 | — | — | EP | disclosed |