Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035749 | 0.82 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL4040406 | 0.79 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL13849034 | 0.79 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL4041809 | 0.78 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL4041549 | 0.78 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL4040391 | 0.78 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL4039534 | 0.78 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4045814 | 0.77 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL4038293 | 0.77 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL13848954 | 0.75 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487797-B1 | HETERO-BRIDGE SUBSTITUTED 8-ARYLQUINOLINE PDE4 INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2009-05-27 | — | — | EP | disclosed |