Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041954 | 0.80 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4041932 | 0.74 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4041415 | 0.73 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL5257745 | 0.71 | CYP2C9 (0.69) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4037670 | 0.69 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4040114 | 0.69 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6682750 | 0.68 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4037325 | 0.67 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL5258978 | 0.66 | CYP2C9 (0.64) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4035622 | 0.66 | CYP2C9 (0.62) | PDE4APDE4BPDE4CPDE4DCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487797-B1 | HETERO-BRIDGE SUBSTITUTED 8-ARYLQUINOLINE PDE4 INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2009-05-27 | — | — | EP | disclosed |