Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.58 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041242 | 0.89 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL4046019 | 0.89 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL13849076 | 0.88 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL4045212 | 0.87 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4042110 | 0.87 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL13849024 | 0.85 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL4035749 | 0.85 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL4371892 | 0.85 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL4037709 | 0.83 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL4027089 | 0.81 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487797-B1 | HETERO-BRIDGE SUBSTITUTED 8-ARYLQUINOLINE PDE4 INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2009-05-27 | — | — | EP | disclosed |