SCHEMBL1385341

SCHEMBL1385341

CC(C)CC1C(=O)N(Cc2ccc3c(N)ncnc3c2)CCN1C(=O)/C=C/c1ccc(Cl)s1

nearest known ligand 0.43

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
F10 P00742 17/20 0.43
DGAT1 O75907 1/20 0.32
ELANE P08246 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1385343 1.00 F10 (0.43) F10DGAT1ELANE
SCHEMBL4392650 0.92 F10 (0.44) F10DGAT1
SCHEMBL1652297 0.92 F10 (0.44) F10DGAT1
SCHEMBL1385902 0.91 F10 (0.45) F10DGAT1
SCHEMBL1385900 0.91 F10 (0.45) F10DGAT1
SCHEMBL4392956 0.90 F10 (0.43) F10DGAT1
SCHEMBL1652830 0.90 F10 (0.43) F10DGAT1
SCHEMBL4387234 0.90 F10 (0.43) F10DGAT1
SCHEMBL4387232 0.90 F10 (0.43) F10DGAT1
SCHEMBL1651524 0.90 F10 (0.43) F10DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4829449-B2 2011-12-07 JP claimed
JP-2003508353-A 2003-03-04 JP claimed
EP-1208097-A2 SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS Aventis Pharmaceuticals Inc. (US) 2002-05-29 EP claimed
WO-2001007436-A2 SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS AVENTIS PHARMACEUTICALS INC. (US) 2001-02-01 WO claimed