Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.38 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2932912 | 0.86 | MAPK14 (0.47) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL1386682 | 0.80 | CCNT1 (0.55) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL2927897 | 0.77 | KDM4E (0.44) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL29652657 | 0.75 | MAPK14 (0.44) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL2929738 | 0.73 | MAPK14 (0.47) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL2929314 | 0.73 | MAPK14 (0.46) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL29893846 | 0.70 | MAPK14 (0.43) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL2930500 | 0.70 | MAPK13 (0.47) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL29652640 | 0.70 | MAPK13 (0.47) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL3257741 | 0.69 | PIK3CG (0.56) | ABL1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4814783-B2 | — | — | 2011-11-16 | — | — | JP | claimed |
| EP-1611131-A1 | PYRAZOLOPYRIDINE DERIVATES | J. Uriach y Compagnia S.A. (ES) | 2006-01-04 | — | — | EP | claimed |
| WO-2004076450-A1 | PYRAZOLOPYRIDINE DERIVATES | J. Uriach Y Compañia S.A. (ES) | 2004-09-10 | — | — | WO | claimed |