SCHEMBL1385538

SCHEMBL1385538

COC[C@H]1C(=O)N(Cc2cc3cnccc3[nH]2)CCN1Cc1ccc(-c2ccc(Cl)s2)cn1

nearest known ligand 0.52

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F10 P00742 13/20 0.52
F2 P00734 2/20 0.41
PRMT5 O14744 1/20 0.34
WDR77 Q9BQA1 1/20 0.34
PDGFRB P09619 1/20 0.30
PDGFRA P16234 1/20 0.30
GPR84 Q9NQS5 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1386332 0.92 F10 (0.54) F10F2PRMT5WDR77
SCHEMBL1385962 0.91 F10 (0.52) F10F2PRMT5WDR77
SCHEMBL1653330 0.88 F10 (0.56) F10F2PRMT5WDR77
SCHEMBL27591289 0.87 F10 (0.43) F10F2PRMT5WDR77PDGFRB
SCHEMBL1385551 0.82 F10 (0.54) F10F2PRMT5WDR77
SCHEMBL1385552 0.82 F10 (0.54) F10F2PRMT5WDR77
SCHEMBL1387140 0.82 F10 (0.63) F10F2PRMT5WDR77
SCHEMBL1652261 0.81 F10 (0.58) F10F2PRMT5WDR77
SCHEMBL1652265 0.81 F10 (0.58) F10F2PRMT5WDR77
SCHEMBL4386777 0.80 F10 (0.49) F10F2PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4829449-B2 2011-12-07 JP claimed
JP-2003508353-A 2003-03-04 JP claimed
EP-1208097-A2 SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS Aventis Pharmaceuticals Inc. (US) 2002-05-29 EP claimed
WO-2001007436-A2 SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS AVENTIS PHARMACEUTICALS INC. (US) 2001-02-01 WO claimed