Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | PRKCQ | Q04759 | 12/20 | 0.52 |
| ▸ | PRKCA | P17252 | 3/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8969925 | 0.89 | PRKCQ (0.65) | KDM4EALDH1A1HSD17B10PRKCQPRKCA | |
| SCHEMBL13857162 | 0.86 | PRKCQ (0.55) | KDM4EALDH1A1HSD17B10PRKCQPRKCA | |
| SCHEMBL8969867 | 0.85 | PRKCQ (0.67) | KDM4EALDH1A1HSD17B10PRKCQPRKCA | |
| SCHEMBL13857238 | 0.84 | PRKCQ (0.55) | PRKCQPRKCAPRKCD | |
| SCHEMBL13857236 | 0.84 | PRKCQ (0.57) | PRKCQPRKCAPRKCD | |
| SCHEMBL13857158 | 0.84 | PRKCQ (0.55) | KDM4EALDH1A1HSD17B10PRKCQPRKCA | |
| SCHEMBL13857160 | 0.84 | PRKCQ (0.56) | KDM4EHSD17B10PRKCQPRKCAPRKCD | |
| SCHEMBL13857179 | 0.84 | PRKCQ (0.54) | KDM4EALDH1A1HSD17B10PRKCQPRKCA | |
| SCHEMBL13857189 | 0.84 | PRKCQ (0.54) | PRKCQPRKCAPRKCD | |
| SCHEMBL13857184 | 0.83 | PRKCQ (0.53) | PRKCQPRKCAPRKCDHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140221334-A1 | KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-08-07 | — | — | US | disclosed |
| US-8741931-B2 | Kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2014-06-03 | — | — | US | disclosed |
| US-20120214799-A1 | KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-08-23 | — | — | US | disclosed |
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |
| US-20110077237-A1 | KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-31 | — | — | US | disclosed |
| US-20090124602-A1 | KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221334-A1 | KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K6 | KDM4E 990/4885ALDH1A1 4211/4885HSD17B10 3343/4885 |
| US-20120214799-A1 | KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K6 | KDM4E 990/4885ALDH1A1 4211/4885HSD17B10 3343/4885 |
| US-20090124602-A1 | KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K6 | KDM4E 990/4885ALDH1A1 4211/4885HSD17B10 3343/4885 |
| US-20110077237-A1 | KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K6 | KDM4E 990/4885ALDH1A1 4211/4885HSD17B10 3343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.