Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.51 |
| ▸ | FPR1 | P21462 | 2/20 | 0.49 |
| ▸ | FPR2 | P25090 | 2/20 | 0.49 |
| ▸ | KDM1A | O60341 | 3/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13858703 | 1.00 | SSTR4 (0.51) | SSTR4FPR1FPR2KDM1AMAOA | |
| SCHEMBL3423982 | 1.00 | SSTR4 (0.51) | SSTR4FPR1FPR2KDM1AMAOA | |
| SCHEMBL17846269 | 0.88 | SSTR4 (0.48) | SSTR4FPR1FPR2KDM1AMAOA | |
| SCHEMBL14818993 | 0.88 | SMN1; SMN2 (0.66) | SSTR4FPR1FPR2KDM1AMAOA | |
| Hydrochloric Acid SCHEMBL13858414 | 0.87 | SSTR4 (0.47) | SSTR4FPR1FPR2KDM1AMAOA | |
| Hydrochloric Acid SCHEMBL13858412 | 0.87 | SSTR4 (0.47) | SSTR4FPR1FPR2KDM1AMAOA | |
| Hydrochloric Acid SCHEMBL13858416 | 0.87 | SSTR4 (0.47) | SSTR4FPR1FPR2KDM1AMAOA | |
| SCHEMBL14804460 | 0.84 | KDM1A (0.46) | SSTR4FPR1FPR2KDM1AMAOA | |
| SCHEMBL13858649 | 0.83 | AKT1 (0.45) | — | |
| SCHEMBL13858498 | 0.83 | AKT1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108329246-B | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as TRKA kinase inhibitors | 阵列生物制药公司 | 2021-02-26 | — | — | CN | disclosed |
| WO-2012158413-A2 | PYRROLIDINYL UREA AND PYRROLIDINYL THIOUREA COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-11-22 | — | — | WO | disclosed |