⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1072263 | 1.00 | — | — | |
| SCHEMBL3245788 | 1.00 | TSHR (0.32) | — | |
| SCHEMBL11613175 | 1.00 | TSHR (0.32) | — | |
| SCHEMBL25162318 | 1.00 | — | — | |
| SCHEMBL1072262 | 1.00 | — | — | |
| SCHEMBL25161927 | 1.00 | — | — | |
| SCHEMBL3245785 | 1.00 | TSHR (0.32) | — | |
| SCHEMBL11613169 | 1.00 | TSHR (0.32) | — | |
| SCHEMBL1535243 | 1.00 | TSHR (0.32) | — | |
| SCHEMBL1535244 | 1.00 | TSHR (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025043219-A1 | METHODS FOR UNCAGING TETRAZINES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-02-27 | — | — | WO | claimed |
| EP-4308168-B1 | METHODS FOR PREPARING CYCLOOCTENES AND CONJUGATES THEREOF | TAGWORKS PHARMACEUTICALS B V (NL) | 2026-05-20 | — | — | EP | disclosed |
| US-12611461-B2 | Bioorthogonal compositions | TAMBO, INC. (US) | 2026-04-28 | — | — | US | disclosed |
| US-20260077076-A1 | AGENTS FOR CLEAVING LABELS FROM BIOMOLECULES IN VIVO | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2026-03-19 | — | — | US | disclosed |
| US-20250255970-A1 | BIOORTHOGONAL COMPOSITIONS | TAMBO INC (US) | 2025-08-14 | — | — | US | disclosed |
| EP-3474901-B1 | CLEAVABLE TETRAZINE USED IN BIO-ORTHOGONAL DRUG ACTIVATION | TAGWORKS PHARMACEUTICALS B V (NL) | 2025-08-06 | — | — | EP | disclosed |
| US-12296017-B2 | Bioorthogonal compositions | TAMBO, INC. (US) | 2025-05-13 | — | — | US | disclosed |
| WO-2025043219-A1 | METHODS FOR UNCAGING TETRAZINES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-02-27 | — | — | WO | disclosed |
| US-12186405-B2 | Cleavable tetrazine used in bio-orthogonal drug activation | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2025-01-07 | — | — | US | disclosed |
| EP-4458896-A2 | BIOORTHOGONAL COMPOSITIONS | Tambo, Inc. (US) | 2024-11-06 | — | — | EP | disclosed |
| WO-2015107064-A1 | MULTIPLE CYCLOADDITION REACTIONS FOR LABELING OF MOLECULES | EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2015-07-23 | — | — | WO | disclosed |
| WO-2015107064-A1 | MULTIPLE CYCLOADDITION REACTIONS FOR LABELING OF MOLECULES | EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2015-07-23 | — | — | WO | disclosed |
| US-20140221395-A1 | Deuterium-Enriched Alkyl Sulfonamides and Uses Thereof | DHANOA DALJIT SINGH (US) | 2014-08-07 | — | — | US | disclosed |
| WO-2014081301-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2014-05-30 | — | — | WO | disclosed |
| WO-2014081300-A1 | CHANNEL PROTEIN ACTIVATABLE LIPOSOMES | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2014-05-30 | — | — | WO | disclosed |
| WO-2014081303-A1 | CHEMICALLY CLEAVABLE GROUP | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2014-05-30 | — | — | WO | disclosed |
| WO-2014081301-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2014-05-30 | — | — | WO | disclosed |
| WO-2014081299-A1 | ACTIVATABLE LIPOSOMES | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2014-05-30 | — | — | WO | disclosed |
| EP-2709667-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | Koninklijke Philips N.V. (NL) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012156919-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) | 2012-11-22 | — | — | WO | disclosed |